Statistical Summary of 2P2IDB 2.0 Interfaces
The table below shows "means" and "standard deviations" of interfaces parameters calculated for the three classes of druggable complexes in 2P2IDB.
| Interface Properties | 2P2IDB |
||
| Class 1 (Protein/Peptide) |
Class 2 (Protein/Protein) |
Class BRD (Bromodomain/Histone) |
|
| Nb of complexes | 10 | 10 | 7 |
| BASA (Å2) | 1284.4 ±251.6 | 2011.9 ±801.6 | 1252.1 ±186.8 |
| % Polar BASA | 53.3 ±18.7 | 73.3 ±16.1 | 58.5 ±7.9 |
| Gap Volume (Å3) | 2143.1 ±1460.4 | 5510.0 ±3290.0 | 1499.0 ±389.6 |
| Non-bonded contacts | 74.3 ±24.9 | 113.1 ±46.3 | 72.4 ±14.1 |
| Total Nb of segments | 4.4 ±1.5 | 8.8 ±2.8 | 3.7 ±0.4 |
| Nb of hydrogen bonds | 2.5 ±1.2 | 4.7 ±2.8 | 2.9 ±1.6 |
| Nb of salt bridges | 0.4 ±1.2 | 0.2 ±0.6 | 0.0 ±0.0 |
2P2Idb v2: Update of a Structural Database Dedicated to Orthosteric Modulation of Protein-Protein Interactions Basse MJ, Betzi S, Morelli X, Roche P. Database update 2016. DOI : 10.1093/database/baw007
2P2Idb: A Structural Database Dedicated to Orthosteric Modulation of Protein-Protein Interactions Basse MJ, Betzi S, Bourgeas R, Bouzidi S, Chetrit B, Hamon V, Morelli X, Roche P. Nucleic Acid Research 2013; 41:D824-827. Pubmed ID: 23203891